Can being poked by pyracantha thorns result in poison-like reactions?

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Yes, being poked by pyracantha thorns can result in poison-like reactions.

Specifically, the shrub in question belongs to the genus Pyracantha. It includes among its common names "firethorn" because of the allergic reactions which contact may provoke in susceptible individuals. The woody plant shelters hydrogen cyanide (HCN) within its parts, especially the berries and the sap. The internal quantity of the toxic poison will be sufficient to irritate the skin through contact with sap and thorns or to provoke diarrhea and vomiting through ingestion of berries.
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Are pyracantha berries poisonous?

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Wild rabbits have stripped all of the bark off of my pyracantha bushes this winter. They have even chewed off some lower limbs and ate them, thorns and all. I am not sure abou
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